Open AccessLinderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
Author(s) -
Xin Liu,
Jing Fu,
Jinshui Yang,
Ancheng C. Huang,
Runfeng Li,
Liping Bai,
Liang Liu,
ZhiHong Jiang,
GuoYuan Zhu
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c06349
Subject(s) - circular dichroism , stereochemistry , chemistry , oxygen , conjugated system , crystallography , organic chemistry , polymer
Linderaggrenolides A-N ( 1-14 ), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata . Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by empirical approaches, electronic circular dichroism calculations, and X-ray crystallography. Compounds 8 and 9 were found to exhibit significant transforming growth factor-β inhibitory activity, with IC 50 values of 25.91 and 21.52 μM, respectively.