Open AccessUnexpected Isomerization of Oxetane-Carboxylic Acids
Author(s) -
Bohdan A. Chalyk,
Anastasiia Grynyova,
Kateryna Filimonova,
Tymofii V. Rudenko,
Dmitry Dibchak,
Pavel K. Mykhailiuk
Publication year - 2022
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.2c01402
Subject(s) - oxetane , chemistry , isomerization , molecule , carboxylic acid , organic chemistry , photochemistry , catalysis
Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these molecules, as this could dramatically affect the reaction yields and lead to negative results (especially in those reactions that require heating).