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Between November 1992 and February 1993, a large outbreak of  Escherichia coli  O157[ratio   ]H7 infections occurred in the western USA and was associated with eating ground beef patties at restaurants of one fast-food chain. Restaurants that were epidemiologically linked with cases served patties produced on two consecutive dates; cultures of recalled ground beef patties produced on those dates yielded  E. coli  O157[ratio   ]H7 strains indistinguishable from those isolated from patients, confirming the vehicle of illness. Seventy-six ground beef patty samples were cultured quantitatively for  E. coli  O157[ratio   ]H7. The median most probable number of organisms was 1·5 per gram (range, &lt;0·3–15) or 67·5 organisms per patty (range, &lt;13·5–675). Correlation of the presence of  E. coli  O157[ratio   ]H7 with other bacterial indicators yielded a significant association between coliform count and the presence of  E. coli  O157[ratio   ]H7 ( P =0·04). A meat traceback to investigate possible sources of contamination revealed cattle were probably initially colonized with  E. coli  O157[ratio   ]H7, and that their slaughter caused surface contamination of meat, which once combined with meat from other sources, resulted in a large number of contaminated ground beef patties. Microbiological testing of meat from lots consumed by persons who became ill was suggestive of an infectious dose for  E. coli  O157[ratio   ]H7 of fewer than 700 organisms. These findings present a strong argument for enforcing zero tolerance for this organism in processed food and for markedly decreasing contamination of raw ground beef. Process controls that incorporate microbiological testing of meat may assist these efforts.

epidemiology and infection

Lessons from a large outbreak of <i>Escherichia coli</i> O157[ratio ]H7 infections: insights into the infectious dose and method of widespread contamination of hamburger patties

Lessons from a large outbreak of Escherichia coli O157[ratio ]H7 infections: insights into the infectious dose and method of widespread contamination of hamburger patties