Open AccessNew approach to an ovine model of hypodynamic endotoxaemia
Author(s) -
Martin Westphal,
Fritz Daudel,
Hans G. Bone,
Hugo Van Aken,
J. Sander,
Henning D. Stubbe,
Michael Booke
Publication year - 2004
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1017/s0265021504008075
Subject(s) - medicine , cardiac index , vascular resistance , pathophysiology , cardiac output , oxygen transport , hemodynamics , shock (circulatory) , septic shock , mean arterial pressure , heart rate , blood pressure , anesthesia , cardiology , oxygen , sepsis , chemistry , organic chemistry
Since the moribund hypodynamic phase of septic shock has primarily been studied in small animal models, the objective of this study was to investigate the usefulness of infusing Salmonella typhosa endotoxin at incrementing doses to establish an ovine model of hypodynamic endotoxaemia.