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Summary  The sex-reversal mutation,  Sxr  and a variant form,  Sxr ′ have been established on the inbred C57BL/6Mcl background by repeated backcrossing to form the CB and CB′ strains, respectively. DNAs of normal  XY, XX Sxr  and  XX Sxr ′ as well as  XY Sxr  and  XY Sxr ′ carrier male mice have been digested with the restriction enzymes  Hae  III and  Hinf  I and electrophoresed. The DNAs show many common but also differing hybridization bands with synthetic   oligonucleotide probes. In  XY Sxr  (and  XY Sxr ′) carrier males, the hybridization patterns of normal  XY  and those of  XX Sxr  (and  XX Sxr ′) males are simply superimposed. Individual differing bands can be categorized by their differential hybridization behaviour to the (GATA) 4 , (GACA) 4 , (GATA) 2  GACA (GATA) 2  and (GATA) 3  (GACA) 2  probes. In general, the hybridization patterns are regularly inherited. In addition to the predominant pattern in each strain, one additional  XX Sxr  and one additional  XX Sxr ′ hybridization pattern was observed: the additional pattern in the CB strain was transmitted (via variant  XY Sxr  carriers) while the secondary  XX Sxr ′ pattern in the CB′ strain could only be observed once. Thus ‘DNA finger printing’ with   oligonucleotide probes can successfully be used to discriminate the DNAs of normal  Y  chromosomes,  XX Sxr  and  XX Sxr ′ variants as well as  XY Sxr  and  XY Sxr ′ carrier mice. Implications of the comparatively high unequal recombination rate involving the murine  Y  chromosome are discussed, as well as possible mechanisms.

Heterogeneity in the Sxr (sex-reversal) locus of the mouse as revealed by synthetic probes