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SUMMARY  In the fungus Podospora anserina , mutations were selected which relieved the hypersensitivity to paromomycin caused by four suppressors assumed to be ribosomal ambiguity mutations ( su  1–31 , su  1–49 , su  1–60 , su  2–5 ). Our first purpose was to isolate new antisuppressor mutations and in fact a new antisuppressor gene, AS  7 was uncovered. The AS  7–1 mutant displays a pleiotropic phenotype and particularly a sporulation defect. On the other hand, a new su  1 mutant was obtained which acts as a suppressor and also as an antisuppressor: it can specifically reduce the suppressor effect of certain su  2 mutations. This property of some su  1 and su  2 mutations was already known. Apart from these mutations probably involved in the control of translational fidelity, six mutations conferring cross-resistance to paromomycin and neomycin were isolated. While four of them are localized in the Pm  1 and Pm  2 loci previously identified, the two others define a new gene which controls paromomycin and neomycin resistance, Pm  3 . Strains carrying the Pm  3–1 allele are sensitive to temperature at the level of growth and sporulation. The three last mutations which were obtained confer no mutant phenotype when separated from the su  1 background. They are closely linked to the su  2 locus.

Mutations relieving hypersensitivity to paromomycin caused by ribosomal suppressors inPodospora anserina