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Dementia is one of the major health threats to our aging society, and Alzheimer's disease (AD) is the leading cause. In Japan, ∼15% of the elderly population has dementia. The apolipoprotein E ( APOE ) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 ( TOMM40 ) gene have been associated with the age of onset of AD. However, differences in allele frequencies of these markers in different ethnic populations are not well known.    Methods  Whole blood samples were collected from 300 Japanese subjects, and genomic DNA was extracted to determine  APOE  alleles and  TOMM40  rs10524523 genotypes.    Results  Our results indicated that the  APOE  ε3– TOMM40 ′523 short haplotype is less frequent in Japanese subjects than in Caucasians, whereas the  APOE  ε3– TOMM40 ′523 long and  APOE  ε3– TOMM40 ′523 very long haplotypes are more frequent in Japanese subjects than in Caucasians. We also showed that the  APOE  ε4– TOMM40 ′523 short haplotype, which was noted to be frequently observed in African Americans, was also found in the Japanese population, although it is extremely rare in the Caucasian population.    Discussion  A biomarker risk assignment algorithm, using a combination of  APOE, TOMM40 ′523 genotype, and age, has been developed to assign near‐term risk for developing the onset of mild cognitive impairment due to AD and is being used as an enrichment tool in an ongoing delay‐of‐onset clinical trial. Understanding the characterization of  APOE  and  TOMM40  allele frequencies in the Japanese population is the first step in developing a risk algorithm for AD research and clinical applications for AD prevention in Japan.

Characterization of APOE and TOMM40 allele frequencies in the Japanese population