Open AccessMultiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development
Author(s) -
Rabinovici Gil D.,
Carrillo Maria C.,
Forman Mark,
DeSanti Susan,
Miller David S.,
Kozauer Nicholas,
Petersen Ronald C.,
Randolph Christopher,
Knopman David S.,
Smith Eric E.,
Isaac Maria,
Mattsson Niklas,
Bain Lisa J.,
Hendrix James A.,
Sims John R.
Publication year - 2017
Publication title -
alzheimer's and dementia: translational research and clinical interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.49
H-Index - 30
ISSN - 2352-8737
DOI - 10.1016/j.trci.2016.09.002
Subject(s) - neuropathology , dementia , disease , medicine , frontotemporal dementia , clinical trial , frontotemporal lobar degeneration , dementia with lewy bodies , lewy body , alzheimer's disease , neuroscience , psychiatry , pathology , psychology
Dementia is often characterized as being caused by one of several major diseases, such as Alzheimer's disease (AD), cerebrovascular disease, Lewy body disease, or a frontotemporal degeneration. Failure to acknowledge that more than one entity may be present precludes attempts to understand interactive relationships. The clinicopathological studies of dementia demonstrate that multiple pathologic processes often coexist. How overlapping pathologic findings affect the diagnosis and treatment of clinical AD and other dementia phenotypes was the topic taken up by the Alzheimer's Association's Research Roundtable in October 2014. This review will cover the neuropathologic basis of dementia, provide clinical perspectives on multiple pathologies, and discuss therapeutics and biomarkers targeting overlapping pathologies and how these issues impact clinical trials.High prevalence of multiple pathologic findings among individuals with clinical diagnosis of AD suggests that new treatment strategies may be needed to effectively treat AD and other dementing illnesses.