Open AccessRod metabolic demand drives progression in retinopathies
Author(s) -
Michael K. Lin,
Soo Hyun Kim,
Lijuan Zhang,
YiTing Tsai,
Stephen H. Tsang
Publication year - 2015
Publication title -
taiwan journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.519
H-Index - 9
eISSN - 2211-5072
pISSN - 2211-5056
DOI - 10.1016/j.tjo.2015.06.002
Subject(s) - medicine , retinitis pigmentosa , oxidative stress , diabetic retinopathy , retinal , macular degeneration , disease , retina , retinal degeneration , ophthalmology , bioinformatics , hypoxia (environmental) , neuroscience , endocrinology , diabetes mellitus , biology , oxygen , chemistry , organic chemistry
Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors.