Epigenetic clock as a correlate of anxiety

Highlights • In young adult women, slower epigenetic clock predicted less symptoms of anxiety.• In young adult women, slower epigenetic clock predicted greater cortical GM volume.• This effect of epigenetic clock in young adult women was largest in frontal lobe.• The link of epigenetic clock and anxiety was mediated by GM volume in frontal lobe.• No similar relationships were found in young adult men or adolescents.