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IC‐P‐098: PHOSPHORYLATION OF SPECIFIC TAU SITES IS ASSOCIATED WITH LOSS OF WHITE MATTER INTEGRITY IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE
Author(s) -
Strain Jeremy F.,
Wisch Julie,
Kilgore Collin B.,
McDade Eric,
Li Yan,
Barthélemy Nicolas R.,
Gordon Brian A.,
Hassenstab Jason,
Fagan Anne M.,
Morris John C.,
Benzinger Tammie L.S.,
Bateman Randall,
Ances Beau M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4941
Subject(s) - white matter , fractional anisotropy , diffusion mri , voxel , pathology , chemistry , neuroscience , psychology , magnetic resonance imaging , medicine , radiology
hyperintensity volumes. Memory and executive domain z-scores and the Neuropsychiatric Inventory were used as cognitive and clinical measures. The area-under-the-curve (AUC) was estimated for discriminating bvAD from bvFTD and typical AD using receiver operating characteristic analysis. Results: Table 2 provides a summary of all measures. The top-3 discriminative variables for bvAD vs bvFTD were posterior (AUC1⁄40.91, 95%CI1⁄4 0.80-1.00) and anterior (AUC1⁄40.83, 95%CI1⁄40.70-0.97) default mode network metabolic connectivity, and parietal hypometablism (AUC1⁄40.80, 95%CI1⁄40.65-0.94). bvAD was discriminated best from tAD by the NPI (AUC1⁄40.79, 95%CI1⁄40.63-0.95), amygdalar grey matter volume (AUC1⁄40.75, 95%CI1⁄40.62-0.88), and anterior default mode network metabolic connectivity (AUC1⁄40.71, 95% CI1⁄40.54-0.89) (Table 3 & Figure 1). Conclusions: Metabolic connectivity metrics and parietal hypometabolism yielded the most optimal contrast between bvAD and bvFTD. Furthermore, bvAD was best distinguished from tAD by amygdalar grey matter, anterior default mode network connectivity and the Neuropsychiatric Inventory. This emphasizes the value of neuroimaging compared to neuropsychological or clinical measures in the differential diagnosis of bvAD. rday, July 13, 2019 P85