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IC‐P‐063: A TOPOGRAPHIC IMAGING BIOMARKER OF TDP43 PATHOLOGY IN AMNESTIC DEMENTIA BASED ON AUTOPSY‐DERIVED FDG‐PET PATTERNS
Author(s) -
Grothe Michel J.,
Lange Catharina,
Nho Kwangsik,
Saykin Andrew J.,
Jelistratova Irina,
Nelson Peter T.,
Buchert Ralph,
Teipel Stefan J.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4906
Subject(s) - hippocampal sclerosis , dementia , pathology , biomarker , autopsy , medicine , imaging biomarker , neuropathology , neuroimaging , hippocampal formation , disease , psychology , neuroscience , magnetic resonance imaging , temporal lobe , radiology , biology , biochemistry , epilepsy
memory, executive function and emotion. SD showed significant positive associations between cerebellar white matter integrity and working memory, language and emotion. Finally, PNFA showed significant positive associations between cerebellar white matter integrity and attention, working memory, visuospatial, language, executive function and emotion. Conclusions: This study is the first to identify distinct patterns of cerebellar white matter changes across FTD syndromes, which in turn relate to discrete cognitive deficits. These findings extend our understanding of the cerebro-cerebellar networks and provide new insight into the mechanisms mediating FTD symptomatology. IC-P-063 ATOPOGRAPHIC IMAGING BIOMARKER OF TDP43 PATHOLOGY IN AMNESTIC DEMENTIA BASED ON AUTOPSYDERIVED FDG-PET PATTERNS Michel J. Grothe, Catharina Lange, Kwangsik Nho, Andrew J. Saykin, Irina Jelistratova, Peter T. Nelson, Ralph Buchert, Stefan J. Teipel, German Center for Neurodegenerative Diseases (DZNE) – Rostock/Greifswald, Rostock, Germany; Charit e – Universitaetsmedizin Berlin, Berlin, Germany; Indiana University School of Medicine, Indianapolis, IN, USA; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; University of Kentucky, Lexington, KY, USA; University Hospital Hamburg-Eppendorf, Hamburg, Germany; Rostock University Medical Center and German Center for Neurodegenerative Disease (DZNE) Rostock, Rostock, Germany. Contact e-mail: michel. grothe@dzne.de