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IC‐P‐130: ICOBRAIN DM: A NEW METHOD FOR HIPPOCAMPUS AND BRAIN LOBE SEGMENTATION IN ALZHEIMER'S DISEASE
Author(s) -
Struyfs Hanne,
Sima Diana M.,
Van Vlierberghe Eline,
Ribbens Annemie,
Claes Lene,
Niemantsverdriet Ellis,
Engelborghs Sebastiaan,
Van Hecke Wim,
Smeets Dirk
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4244
Subject(s) - atrophy , temporal lobe , brain size , medicine , alzheimer's disease , cognitive impairment , segmentation , population , psychology , nuclear medicine , pathology , audiology , cardiology , disease , magnetic resonance imaging , radiology , psychiatry , artificial intelligence , epilepsy , computer science , environmental health
approach. Results: Classifying using PH features provides more discriminative power compared to mesh features (Fig2. AvsC and BvsD). Residualizing age from the cortical thickness meshes resulted in better performance overall in prediction of MCI (Fig.2 AvsB and CvsD). Kernels built from age-regressed homological features achieved the greatest AUC (0.735, Fig.2D). Conclusions: Building a coarse descriptor of topology improves discriminative power of whole brain atrophy biomarkers at the MCI stage. Regressing out effects of age further improves discriminative power. Our results collectively show that homological features prove useful in identifying individuals with early stages of cognitive impairment. IC-P-130 ICOBRAIN DM: A NEW METHOD FOR HIPPOCAMPUS AND BRAIN LOBE SEGMENTATION IN ALZHEIMER’S DISEASE Hanne Struyfs, Diana M. Sima, Eline Van Vlierberghe, Annemie Ribbens, Lene Claes, Ellis Niemantsverdriet, Sebastiaan Engelborghs, Wim Van Hecke, Dirk Smeets, icometrix, Leuven, Belgium; Institute Born-Bunge, Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; icometrix, Boston, MA, USA; University of Antwerp, Antwerp, Belgium; UZ Brussel and Vrije Universiteit Brussel (VUB), Brussels, Belgium. Contact e-mail: eline.vanvlierberghe@ icometrix.com