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P2‐427: THE RELATIONSHIP BETWEEN HISPANIC ETHNICITY, AMYLOID LOAD AND APOE4 CARRIER STATUS
Author(s) -
Duara Ranjan,
Loewenstein David A.,
Lizarraga Gabriel,
Adjouadi Malek,
Barker Warren W.,
Greig-Custo Maria T.,
Rosselli Monica,
Curiel Rosie E.,
Hanson Kevin,
Marsiske Michael,
Ertekin-Taner Nilufer,
Vaillancourt David,
DeKosky Steve,
Santi Susan,
Golde Todd E.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2834
Subject(s) - ethnic group , dementia , medicine , psychology , demography , disease , sociology , anthropology
partial volume corrected. Associations between LC intensity, age, Ab, tau and memory were evaluated with Spearman correlations in both groups.Groups were compared with the Mann-Whitney-U test. Results: The two groups did not differ in LC intensity (p1⁄40.26), but carriers showed a negative association with age (r1⁄4-0.55, p1⁄40.043), non-carriers did not (r1⁄4-0.25, p1⁄40.40). There was a marginal negative association with Ab in the carriers (r1⁄40.49, p1⁄40.08), and a significant association in the non-carriers (r1⁄4-0.57, p1⁄40.045) and overall group (r1⁄4-0.51, p1⁄40.007; controlling for group: r1⁄4-0.55, p1⁄40.004). LC intensity correlated negatively with entorhinal tau in the overall group (r1⁄4-0.47, p1⁄40.014), in the carriers (r1⁄4-0.59, p1⁄40.03), but not in non-carriers (r1⁄4-0.12, p1⁄40.71, Fig2). Finally, LC intensity correlated positively with word list learning at trend-level in carriers (r1⁄40.52, p1⁄40.055), but not in non-carriers (r1⁄40.008, p1⁄40.98, Fig3). Conclusions: Measures of LC intensity relate to early accrual of Ab and tau as well as to memory performance in preclinical autosomal dominant Alzheimer’s disease (ADAD). These preliminary findings in this limited sample suggest that degeneration of the noradrenergic LC may be an early and prominent phenomenon related to the pathologic sequela of ADAD that contribute to memory function prior to dementia-onset.