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P2‐338: ALZHEIMER'S PATHOLOGIC CHANGES IN SUBJECTIVE COGNITIVE DECLINE USING SELF‐REPORT QUESTIONNAIRE AND IMAGING BIOMARKERS
Author(s) -
Hong Yun Jeong,
Park Jeong Wook,
Kim Seong Hoon,
Shin Hae Eun,
Lee Si Baek,
Ryu Dong Woo,
Kim Yong Bang,
Park Kyung Won
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2745
Subject(s) - cognitive decline , neuropsychology , cognition , medicine , feeling , clinical psychology , disease , biomarker , psychology , dementia , gerontology , psychiatry , social psychology , biochemistry , chemistry
(AUC 1⁄4 0.911) was obtained using a three-variable model combining perceptual speed, hippocampal volume, and white-matter integrity of the forceps-major tract. Conclusions: This study indicates that using markers from different modalities to predict future dementia can improve the detection of people with increased risk. Global measures showed the best prediction results here. Moreover, adding assessment of white-matter integrity can add unique information to prediction models. However, the added benefit was relatively small and should beweighed against economical and practical aspects when resources are limited.