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P2‐326: MRI‐BASED BRAIN VOLUMETRY IN SINGLE‐ AND MULTI‐DOMAIN AMNESTIC MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE
Author(s) -
Shi Lin,
Wong Leongtim,
Liu Jianghong,
Wang Defeng,
Li Kuncheng,
Liang Peipeng
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2733
Subject(s) - atrophy , cognitive impairment , magnetic resonance imaging , audiology , psychology , brain size , analysis of variance , cardiology , hippocampus , alzheimer's disease , medicine , temporal lobe , subgroup analysis , cognition , neuroscience , disease , radiology , confidence interval , epilepsy
anterior area and the ADC value of the lesions in the right ventricle posterior area tended to increase (P1⁄40.058, P1⁄40.058). When the three parameters of white matter lesions were correlated with clinical features, it was found that FA of right ventricular anterior area was significantly correlated with motor function, cognitive and functional score and iNPHGS score. Conclusions: Periventricular white matter lesions in patients with idiopathic normal pressure hydrocephalus are significantly correlated with their clinical features, which may be one of the pathogenesis and the target of improving symptoms after drainage surgery. This project was supported by grant from CAMS 2016-12M-1-004, National NSFC81550021, 2016YFC1306300, grant XDPB10.