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F5‐05‐04: THE USE OF RESIDUAL METHODS TO CAPTURE COGNITIVE RESERVE AND STUDY CLINICAL PROGRESSION IN ALZHEIMER'S DISEASE
Author(s) -
Loenhoud Anita C.,
Flier Wiesje M.,
Wink Alle Meije,
Dicks Ellen,
Groot Colin,
Twisk Jos WR.,
Barkhof Frederik,
Scheltens Philip,
Ossenkoppele Rik
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2987
Subject(s) - cognitive reserve , cognition , dementia , psychology , cognitive decline , biomarker , neuroimaging , neuropathology , population , disease , clinical dementia rating , cognitive impairment , clinical psychology , medicine , neuroscience , biochemistry , chemistry , environmental health
Figure 1. Schematic representation of an individual with high cognitive reserve (A) and an individual with low cognitive reserve (B). Compared to individual B, individual A has a higher premorbid level of cognitive functioning, and is able to maintain this premorbid level at more advanced levels of neuropathology. After their inflection point, however, individual A declines more rapidly than individual B. When both subjects first present with significant cognitive impairment ("score at incident AD visit") individual Awill have more underlying pathology than individual B. Reprinted with permission from Stern, Lancet Neurol, 2012,11,1006 1012, Elsevier.