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P3‐459: ALTERATIONS IN AUTOPHAGY IN FRONTOTEMPORAL DEMENTIA
Author(s) -
Heale Richard,
Stan Diana Madalina,
Smyth Lucy,
Lace-Costigan Gemma
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1823
Subject(s) - c9orf72 , frontotemporal dementia , autophagy , frontotemporal lobar degeneration , grey matter , dementia , biology , frontal lobe , pathology , neuroscience , psychology , medicine , white matter , disease , genetics , magnetic resonance imaging , apoptosis , radiology
Sample size* 67 19 1539 Demographic differences Females 36/67 (54%) 9/19 (47%) 830/1539 (54%) 0.850 Education, years 12 (12,16) 13 (12,16) 14 (12,16) 0.055 Job level score 4 (3,6) 3 (3,6) 4 (3,6) 0.898 APOE ε4 32/62 (52%) 10/14 (71%) 727/1132 (64%) 0.110 Family history of cognitive impairment 38/66 (58%) 5/17(29%) 522/1417(37%) 0.002 Age at death, years 82 (76,86) 78 (73,82) 82 (76,87) 0.217 Clinical differences Age onset of cognitive impairment, years. 70 (61,75) 70 (67,75) 72 (66,78) 0.046 Disease duration, years 12 (8,14) 8(6,10) 9(6,12) <0.001 Cognitive decline on MMSE, pts/year** -1.8 (-4.2,-0.4) -3.6 (-4.8,0.5) -1.6 (-3.8,-0.2) 0.715 MMSE score proximal to death, points*** 4.0 (1.3,7.0) 9.5(4.8,16.3) 14.0 (7.0,19.0) <0.001 Neuropathologic differences Brain weight, g. 960 (880,1080) 940 (860,1200) 1040 (940,1140) 0.001 Thal amyloid phase 5 (5,5) 5 (4,4) 5 (5,5) 0.451 Braak tangle stage VI (V,VI) V (V,VI) VI (V,VI) 0.015 TDP-43 positivez 18/40 (45%) 7/13 (54%) 352/886 (40%) 0.479 Lewy body diseasez 17/67 (25%) 4/19 (21%) 377/1539 (24%) 0.928