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P1‐165: A NOVEL APP VAL604MET MUTATION IN A THAI WITH EARLY‐ONSET ALZHEIMER DISEASE
Author(s) -
Van Vo Giau,
Senanarong Vorapun,
Bagyinszky Eva,
Limwongse Chanin,
An Seong Soo,
Kim SangYun
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.169
Subject(s) - early onset alzheimer's disease , exon , disease , amyloid precursor protein , dementia , gene , mutation , genetics , medicine , alzheimer's disease , biology , pathology
Association analysis of twenty-three AD risk genes and nine DTI features from the discovery samples in ADNIGO/2 using common variants (minor allele frequency 0.05) where empirical p-values were calculated using 20,000 permutations in PLINK. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (LI), radial diffusivity (RD), linearity of the tensor (LIN), sphericity of the tensor (SPH), planarity of the tensor (PLA), mode of the tensor (MOD), orientation dispersion index (ODI)