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P1‐132: DISRUPTION OF CHOLINERGIC NEUROTRANSMISSION, WITHIN A COGNITIVE CHALLENGE PARADIGM, PREDICTS Aβ‐RELATED COGNITIVE IMPAIRMENT IN PRECLINICAL ALZHEIMER'S DISEASE AFTER A 27‐MONTH DELAY INTERVAL
Author(s) -
Goldfarb Danielle,
Snyder Peter J.,
Maruff Paul,
Santos Cláudia Y.,
Ott Brian R.,
Salloway Stephen,
Yoo Don C.,
Noto Richard B.,
Alber Jessica,
Thompson Louisa I.,
Song Alex
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.135
Subject(s) - basal forebrain , cholinergic , cognitive decline , neuroscience , atrophy , psychology , cholinergic neuron , dementia , entorhinal cortex , medicine , alzheimer's disease , hippocampus , cognition , donepezil , disease
Figure 1. Performance on the International Shopping List (ISLT) Delayed Recall Task, by participants who either failed the scopolamine challenge test (SCT) at baseline (N 1⁄4 28, at end of study) vs. those who passed the SCTat baseline (N1⁄4 30, at end of study), modeled over all four study visits. Dark lines indicate group mean scores at each visit, with SE bars provided. Both betweenand within-subject variation is represented in each group, by displaying individual subject change over time, with each case yoked to the group baseline mean score. Danielle Goldfarb, Peter J. Snyder, Paul Maruff, Cl audia Y. Santos, Brian R. Ott, Stephen Salloway, Don C. Yoo, Richard B. Noto, Jessica Alber, Louisa I. Thompson, Alex Song, Alpert Medical School of Brown University, Providence, RI, USA; University of Rhode Island, Kingston, RI, USA; The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; Cogstate Ltd., Melbourne, Australia; Lifespan, Providence, RI, USA; Butler Hospital, Providence, RI, USA; Brown University, Providence, RI, USA. Contact e-mail: dagoldfarb9@gmail.com