P2‐589: PREVALENCE OF POTENTIALLY INAPPROPRIATE MEDICATION USE AND INTERACTIONS IN A PRIVATELY INSURED ELDERLY POPULATION

cohort is the chilean core clinical project of the new Gerocenter on Brain Health and Metabolism (GERO). Methods: The Gero cohort aims at recruiting 300 elderly subjects (>70 years) from three areas of Santiago(Chile) following them up for at least 3 years. Eligible people are non-demented adults with a subjective cognitive complaint, which is reported by the participant and/or a knowledgeable informant. Participants are identified through a household census . The protocol of evaluation is based on a multidimensional approach: socio-demographic, general medical/ nursing, psychosocial, neuropsychological, neuropsychiatric, motor, neuroimaging, blood biomarkers and a genetic sample. Gero’s biobank stores blood samples which keep for long-term storage at -80 C in liquid nitrogen. The multidimensional protocol of evaluation is administered in months 0 (baseline), 18, and 36. In addition, in months 6, 24, and 30 a telephone interview will be done to collect data for a follow up protocol. Results: To our date the Gero cohort now includes over 50 subjects, and the majority of these have had a multilevel assessment and blood intake. Conclusions: Our work will allow us to determine the risks factors (biomedical, clinical and psychosocial) associated with the prognosis of elderly with cognitive complaint on the evolution to a significant functional decline. The Gero cohort will help to design public health policies tailored to prevent aging disease, and contribute to a better understanding of cognitive impairment and dementia in Latin America and the world. Gero’s aim is to establish a center for studying Brain Ageing in Chile including basic and clinical research.