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P2‐395: TESTING MAINTENANCE AND COMPENSATION NOTIONS IN NORMAL AGING: AGE‐RELATED CORRELATES OF ASSOCIATIVE ENCODING SUCCESS
Author(s) -
Vidal-Piñeiro Didac,
Markus Sneve H.,
Nyberg Lars,
Mowinckel Athanasia M.,
Sederevicius Donatas,
Walhovd Kristine B.,
Fjell Anders M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1086
Subject(s) - episodic memory , psychology , context (archaeology) , content addressable memory , neuropsychology , encoding (memory) , retrospective memory , cognitive psychology , cognition , developmental psychology , neuroscience , explicit memory , computer science , artificial intelligence , paleontology , artificial neural network , biology
Background:Approximately 20-30% of CN are amyloid-positive in the amyloid b imaging. When assessed in CN, hippocampal atrophy has been reported in amyloid-positive cases in few studies but not in others. The relationship between the Ab deposition and the hippocampal volume is hence debatable. Recent technical advancements enable us to dissect the subfields of the hippocampus. The total hippocampal volume and the subfield volumes can show different atrophy patterns in amyloid-positive cases. We aimed to investigate the atrophy patterns of whole hippocampus and subfields in amyloid positive cases. Methods:Seventy nine subjects underwent T1-weighted structural MRI and amyloid PET imaging. Based on the amyloid PET scans, the subjects were classified into amyloid negative and positive groups (50 and 29, respectively). The hippocampal subfield volumes were measured from the MRI using FREESURFER v6.0. To compare the volumes between the two groups, general linear model was used after adjusting for age, sex, level of education, intra-cranial volume (ICV), and the presence of APOE ε4 allele. Results:The analysis was performed for volumes of the left and right hemispheres separately. Each subfield mean were compared between the two groups and then corrected for multiple comparisons. Neither the whole hippocampal volume nor the hippocampal subfields volume showed significant differences between the amyloid positive and negative groups, bilaterally after the correction. Conclusions: The findings suggest that the elevated amyloid levels in the preclinical stage of AD may not have significant influence on the hippocampal volume.