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P2‐391: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY
Author(s) -
Ohene Yolanda,
Harrison Ian F.,
Nahavandi Payam,
Ismail Ozama,
Ottersen Ole P.,
Nagelhus Erlend A.,
Thomas David L.,
Lythgoe Mark F.,
Wells Jack A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1082
Subject(s) - parenchyma , aquaporin 4 , glymphatic system , medicine , perfusion , pathology , perfusion scanning , clearance , cardiology , urology , cerebrospinal fluid
Mean difference in hippocampal subfield volumes (mean of left and right) between groups using linear regression models. Key: YOAD1⁄4young onset Alzheimer’s disease; HC 1⁄4 Healthy controls; Typ AD1⁄4amnestic led typical Alzheimer’s disease; PCA1⁄4posterior cortical atrophy (visual symptom led Alzheimer’s disease);95%CIS1⁄4 95% confidence intervals; TIV1⁄4total intracranial volume; GC-DG1⁄4Molecular and Granule Cell Layers of the Dentate Gryus; HATA1⁄4Hippocampal Amygdala Transition Area; *p<0.05 – standard statistical threshold; **p1⁄4<0.004 Bonferroni corrected threshold