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[O5–05–05]: IMPACT OF APOE GENETIC VARIANT ON BRAIN MORPHOLOGY IN A COHORT OF COGNITIVELY HEALTHY MIDDLE‐AGED INDIVIDUALS WITH ENRICHED GENETIC RISK FOR ALZHEIMER's DISEASE
Author(s) -
Cacciaglia Raffaele,
Molinuevo José Luis,
Falcon Carles,
Brugulat Anna,
SánchezBenavides Gonzalo,
Gramunt Nina,
Esteller Manel,
Moran Sebastian,
Minguillon Carolina,
Fauria Karine,
Gispert Juan Domingo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.535
Subject(s) - apolipoprotein e , precuneus , grey matter , disease , brain morphometry , psychology , voxel based morphometry , neuroscience , hippocampus , neuroimaging , alzheimer's disease , oncology , medicine , cognition , magnetic resonance imaging , white matter , radiology
526 middle-aged healthy adults. A) Mean-centered bar plots showing GM volumetric differences among the five APOE genotype groups. Spatial coordinates are given in the Montral Neurological Institute (MNI) standard space. B) Statistical parametric maps displaying main effects of APOE genotype on GM volumes. The bilateral hippocampus and thalamus are represented in cold and warm colors, respectively. Podium Presentations: Thursday, July 20, 2017 P1465