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[O3–07–06]: THE RELATIONSHIP BETWEEN RECALL OF RECENTLY VERSUS REMOTELY ENCODED FAMOUS FACES AND AMYLOID AND TAU BURDEN IN CLINICALLY NORMAL OLDER ADULTS
Author(s) -
Orlovsky Irina,
Mormino Beth C.,
Huijbers Willem,
Schultz Aaron P.,
Rentz Dorene M.,
Sperling Reisa A.,
Johnson Keith,
Papp Kate V.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.07.343
Subject(s) - recall , psychology , medicine , cognitive psychology , audiology
covariates.Models included all participants so thatWMH/cognition relationships could be explored independently from diagnostic category. Results:Right dorsolateral WMH volumes were negatively associated with Rey copy score (b1⁄4-2.6, p<.001); left dorsolateral WMH volumes were negatively associated with WCST total correct trials (b1⁄40.9, p1⁄4.036). Post-hoc analyses showed that WMH/Rey associations were driven primarily by AD participants, whileWMH/WCSTassociations were driven by CIND participants. Conclusions:Results indicate that not all executive functions are affected equally by SVD, and regional distribution of WMH may be selectively associated with different tests. Determining specific associations between SVD/executive processes at different stages of AD is the first step in developing targeted process-specific treatments, which may improve other areas of cognition downstream. This study increases understanding of brain-behavior relationships in SVD, a potentially modifiable risk factor for dementia, in the context of cognitive symptoms in persons with or at risk for AD.