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[IC‐P‐206]: PARAMETRIC IMAGING OF TAU LOAD IN ALZHEIMER's PATIENTS AND CONTROLS USING FLORTAUCIPIR
Author(s) -
Wolters Emma E.,
Golla Sandeep S.V.,
Timmers Tessa,
Ossenkoppele Rik,
Groot Colin,
Weijden Chris W.J.,
Verfaillie Sander C.J.,
Scheltens Philip,
Flier Wiesje M.,
Schwarte Lothar A.,
Mintun Mark A.,
Devous Michael D.,
Schuit Robert C.,
Windhorst Albert D.,
Lammertsma Adriaan A.,
Boellaard Ronald,
Berckel Bart N.M.,
Yaqub Maqsood M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2582
Subject(s) - positron emission tomography , nuclear medicine , parametric statistics , mathematics , binding potential , volume of distribution , biomedical engineering , medicine , statistics , pharmacokinetics
(F1,311⁄412.367, p1⁄40.001). Tau deposition correlated to CMRGlu in superior parietal cortex (F1,311⁄44.856; p1⁄40.035). No correlation was demonstrated between tau deposition and CMRO2and CBF. Conclusions: Our findings support the hypothesis that in regions known to accumulate AD pathology, higher levels of AG are associated with lower pathological burden, suggesting that high AG promotes resilience to progression of AD pathology.