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[P4–126]: δ‐SECRETASE–CLEAVED TAU STIMULATES Aβ PRODUCTION VIA ACTIVATING STAT1‐BACE1 PATHWAY IN ALZHEIMER's DISEASE
Author(s) -
Ye Keqiang,
Zhang Zhentao,
Wang JianZhi,
Liu Gongping,
Yu ShanPing,
Li XiaoGuang
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1992
Subject(s) - amyloid precursor protein secretase , pathogenesis , amyloid precursor protein , presenilin , chemistry , microbiology and biotechnology , stat1 , phosphorylation , kinase , alzheimer's disease , biology , medicine , immunology , disease
phenotypes were analyzed in cortex. Results:We demonstrate that molecular chaperone BRICHOS domains significantly decreased Ab levels, inhibited amyloid accumulation, greatly reduced astroglial activation, and prevented cognitive decline in APP/PS1 mice. Conclusions: Together, our results show that the molecular chaperone BRICHOS domain promotes protein homeostasis and decreases the severity of Ab aggregation and its associated pathology in the brain. These data suggest that the BRICHOS domain can be further investigated as a promising preventive and therapeutic strategy against AD.