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[P4–029]: AMYLIN RECEPTOR LIGANDS REDUCE THE PATHOLOGICAL CASCADE OF ALZHEIMER's DISEASE
Author(s) -
Zhu Haihao,
Wolozin Benjamin,
Qiu Wendy
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1893
Subject(s) - amylin , receptor , chemistry , medicine , amyloid (mycology) , endocrinology , neuroscience , microbiology and biotechnology , biology , insulin , islet , inorganic chemistry
cognitive decline. Interestingly, prebiotics, probiotics or synbiotics shared similarly efficacy for improving insulin sensitivity, brain mitochondrial function, synaptic plasticity, and restoring cognitive function (Fig.1). Moreover, synbiotics was the best therapy in reducing brain oxidative stress. Conclusions:These findings suggest that prebiotics, probiotics or synbiotics prevents cognitive decline in obese-insulin resistant model via reducing brain oxidative stress, restoring brain mitochondrial function and improving synaptic plasticity.