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[P3–193]: CEREBROSPINAL FLUID ALPHA‐SYNUCLEIN IN MILD COGNITIVE IMPAIRMENT PATIENTS: A PRELIMINARY STUDY
Author(s) -
MongeArgilés José Antonio,
Rueda Francisco Navarrete,
Robles Jorge Manzanares,
García Victoria Monge,
Leiva Santana Carlos
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.1405
Subject(s) - cerebrospinal fluid , medicine , lumbar puncture , dementia , mini–mental state examination , biomarker , neurological examination , cognitive impairment , neuropsychology , physical examination , lewy body , gastroenterology , disease , psychiatry , cognition , biochemistry , chemistry
and the covariance parameters between the baseline CSF Ab42, TAU and PTAU volume change over time indicated that OSA participants experienced a faster decrease in CSF Ab42 and increases in TAU and PTAU volumes over time (p < .0001 for all) in both the CN and MCI groups. Conclusions: OSA possibly accelerates longitudinal changes in brain amyloid deposition, and CSF biomarkers burden, both in elderly cognitive normal and MCI individuals. Further research examining mechanisms underlying these observed effects are needed.