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IC‐P‐208: Secretion of Ab Peptides From Human Platelets
Author(s) -
Alexander Smirnov
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.240
Subject(s) - secretion , platelet , amyloid precursor protein , chemistry , thrombin , peptide , biochemistry , platelet activation , protein precursor , microbiology and biotechnology , alzheimer's disease , biology , medicine , immunology , enzyme , disease
an initial assessment of the relationship of [F]AV-1451 tau markers to measures of cognition and atrophy in participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Methods: 20 participants from ADNI-2 underwent [F] AV-1451 scans, structural MRI within approximately 6 months of the [F]AV-1451 (mean1⁄40.48 years, range 1⁄4 0-2.2 years) and cognitive assessments (memory composite, self and informant ECog) within approximately 6 months of the [F]AV-1451 scanning (mean1⁄4 0.4 years; range1⁄4 0-1.27 years). [F]AV-1451 scans were processed usingmethods similar to those previously described [1] and intensity normalized to the cerebellar grey matter. [F]AV1451 SUVR was extracted from the medial temporal (hippocampus, entorhinal cortex, and parahippocampal gyrus) and the posterior cingulate, a region known to be linked to the hippocampus as part of the default mode network. Finally, relationships between these [F]AV-1451 SUVR measures and hippocampal volume estimates (Freesurfer v5.1) and cognitive assessments were performed (covaried for age, time between [F]AV-1451 and cognitive/MRI assessments, total intracranial volume (ICV), and/ or gender where appropriate). Results:Significant associations between [F]AV-1451 SUVR in the medial temporal lobe and posterior cingulate and a memory composite score were observed (p<0.05; Figure 1A & 1B). Self and informant memory complaints were also significantly associated with medial temporal lobe [F] AV-1451 SUVR (p<0.05; Figure 1C & 1D). Finally, significant associations of both medial temporal lobe and posterior cingulate [F]AV-1451 SUVR and hippocampal volume were also observed (p<0.05; Figure 1E & 1F). Conclusions: Associations between cognition, subjectand informant-based cognitive complaints, and neurodegeneration and medial temporal and posterior cingulate [F]AV-1451 SUVR support the theory that neurofibrillary tau tangles, neurodegeneration, and cognition are closely linked. Future longitudinal studies will help to elucidate the timing and ordering of changes in these biomarkers and clinical symptoms. [1] Risacher et al. (2015) Alzheimer’s & Dementia, (11): 1417.