P2‐145: Reduced Cerebrovascular Reserve Capacity During Moderate Intensity Exercise in People with Elevated B‐Amyloid

jectories (e.g., Figure 2) accelerated from normal to abnormal levels for both ADAD and LOAD, with some evidence for plateauing/deceleration (consistent with sigmoidal behavior) beyond symptom onset. Conclusions: We found data-driven support for broadly similar biomarker progression of ADAD and LOAD (only minor differences), thus supporting research findings in ADAD being applicable to LOAD. Our data-driven model-based approaches increase understanding of pathological cascades with potential utility for patient staging and prognosis.