S5‐01‐01: Novel CSF biomarkers of synaptic dysfunction

not available. S5-01-04 ALZBIOMARKER DATABASE ON ESTABLISHED AND NOVEL CSFAND PLASMA BIOMARKERS FOR ALZHEIMER’S DISEASE Bob Olsson, Ronald Lautner, Ulf Andreasson, Annika € Ohrfelt, Erik Portelius, Maria Bjerke, Mikko H€oltt€a, Christoffer Rosen, Kelly Dakin, Elisabeth Wu, Caroline Olsson, Max Petzold, Kaj Blennow, Henrik Zetterberg, University of Gothenburg, M€olndal, Sweden; Alzforum, Boston, MA, USA; University of Gothenburg, Gothenburg, Sweden. Contact e-mail: bob.olsson@neuro.gu.se not available. THURSDAY, JULY 23, 2015 FEATURED RESEARCH SESSIONS F5-01 BRAIN CORRELATES OF MODIFIABLE LIFESTYLE RISK FACTORS FOR ALZHEIMER’S DISEASE: FROM ANIMAL RESEARCH TO INTERVENTION TRIALS F5-01-01 CALORIE RESTRICTION IMPROVES BRAIN HEALTH IN AGING RHESUS MACAQUES Sterling C. Johnson, Geriatric Research Education and Clinical Center, Wm. S. Middleton Veterans Hospital, Madison, WI, USA; Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Contact e-mail: scj@medicine.wisc.edu Background:Calorie restriction (CR) without malnutrition slows the aging and disease process, prolonging median and maximum lifespan in yeast, worms, fish, flies, and rodents. Studies of CR in non-human primates (Macaca mulatta) indicate a protective effect of CR against aging-related diseases and a salutary effect on brain health.Methods: Our group has studied the specific effects of CR on the non-human primate brain using neuroimaging, behavioral, and post-mortem histological techniques and this talk will provide an