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O4‐07‐05: 18F‐(S).THK5117 as a PET tracer for tau pathology in Alzheimer's disease and non‐alzheimer's disease dementia
Author(s) -
Nordberg Agneta
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.07.385
Subject(s) - tau pathology , voxel , nuclear medicine , dementia , white matter , alzheimer's disease , medicine , positron emission tomography , pathology , radiology , disease , magnetic resonance imaging
window (e.g., to better categorize cohorts or reach SUVR steady state) should be made with caution as noise for some scans started increasing at 50 minutes. The regional clearance rate k2 might be explored as an additional metric and could be esimtated from dynamic 80-100 (or 75-105) minute scans. Further dynamic studies are planned and additional evaluation of kinetic modeling methodologies is warranted.