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P2‐188: Characterization of cognitive function with the cantab in individuals with amnestic mild cognitive impairment in relation to hippocampal volume, amyloid, and tau status: Preliminary baseline results from the PharmaCog/european‐ADNI study
Author(s) -
Nathan Pradeep J.,
Galluzzi Samantha,
Marizzoni Moira,
Cotelli Maria,
Babiloni Claudio,
Bartres-Faz David,
Bordet Regis,
Bosch Beatriz,
Anna Francesca,
Didic Mira,
Farotti Lucia,
Forloni Gianluigi,
Jovicich Jorge,
Marra Camillo,
Marzano Nicola,
Molinuevo Jose Luis,
Nobili Flavio,
Pariente Jeremie,
Parnetti Lucilla,
Payoux Pierre,
Picco Agnese,
Ranjeva Jean-Philippe,
Roccatagliata Luca,
Rossini Paolo,
Salvadori Nicola,
Schonknecht Peter,
Berwig Martin,
Hensch Tilman,
Soricelli Andrea,
Tsolaki Magda,
Vecchio Fabrizio,
Visser Pieter Jelle,
Wiltfang Jens,
Orlandi Daniele,
Blackwell Andrew,
Abbott Rosemary A.,
Blin Olivier,
Frisoni Giovanni Battista
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.727
Subject(s) - hippocampal formation , episodic memory , hippocampus , psychology , medicine , cerebrospinal fluid , biomarker , population , neuroscience , alzheimer's disease , cognitive decline , cognition , neurodegeneration , oncology , dementia , disease , chemistry , biochemistry , environmental health
Braak IV case as compared to a Braak II case. Beside that we also detected an increased presence of ThioflavinS positive NFTs and pThr231 Tau in late stage somata and neurites. In hippocampi however, elevated hyperphosphorylation of pTyr18 and pThr231 Tau occurs already at Braak stages I/II, while NFT formation follows afterwards. Conclusions: Our results suggest especially Tau hyperphosphorylation at residues Tyr18 and Thr231 are early events in hippocampal degeneration and highlight the possible link to early memory loss in AD subjects. Whereas, NFTs, pSer202/Thr205 and pSer262 IR dystrophic neurites present as later stage features. Further studies are warranted to clarify the role of C terminal phosphorylation at Ser396 and Ser422 for the progression of AD.