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P1‐268: Variants in candidate genes for Alzheimer's disease are associated with declining plasma abeta peptides in adults with down syndrome
Author(s) -
Schupf Nicole,
Dang Lam-Ha,
Lee Annie,
Pang Deborah,
Zigman Warren B.,
Luchsinger Jose A.,
Krinsky-McHale Sharon,
Silverman Wayne,
Tycko Benjamin,
Kisselev Sergey,
Clark Lorraine,
Lee Joseph H.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.469
Subject(s) - chromosome 21 , allele , genetics , single nucleotide polymorphism , apolipoprotein e , down syndrome , dementia , genotyping , biology , candidate gene , pathogenesis , genotype , chromosome , chromosome 9 , snp , gene , medicine , alzheimer's disease , disease
Sex Male 1 1 Female 0.9 (0.6-1.3) 0.8 (0.5-1.4) Age group (year)(68-72) 1 1 1 73-77 5.7 (2.5-12.8) 7.0 (2.4-20.5) 5.6 (2.4-12.7) 78-82 8.3 (3.6-18.0) 11.2 (3.8-33.4) 7.1 (3.1-16.3) 83+ 13.0 (5.9-29.0) 18.0 (6.1-52.4) 11.1 (5.0-25.0) Education Middle/high school 1 1 1 Primary/secundary 4.7 (0.7-34.0) 3.6 (0.5-28.3) 3.7 (0.5-28.3) None/incomplete primary 10.9 (1.6-75.3) 4.9 (0.6-37.0) 5.6 (0.7-41.3) Area of study Urban 1 1 1 Rural 2.3 (1.5-3.1) 1.3 (0.7-2.3) 18 (1.1-2.7) Type 2 diabetes meillitus No case 1 1 1 Incident 1.3 (0.3-5.3) 0.8 (0.1-5.8) 1.1 (0.2-4.8) Prevalent 18 (1.2-2.6) 2.1 (1.2-3.5) 2.2 (1.5-3.2) Dyillptdemla No case 1 1 Prevalent 1.0 (0.7-1.6) 1.6 (0.8-3.0) Hypertension No case 1 1 Incident 1.3 (0.7-2.6) 2.0 (0.5-5.0) Prevalent 0.8 (0.5-1.1) 0.6 (0.3-0.9) Control of hypertension No case 1 Controlled cases 0.8 (0.5-1.1) Poster Presentations: P1 P458