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P4‐163: A single dose of the beta‐secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys
Author(s) -
Matijevic Mark,
Watanabe Hideki,
Sato Yoshiaki,
Bernier Francois,
McGrath Shan,
Burns Lynne,
Yamamoto Noboru,
Ogo Makoto,
Dezso Zoltan,
Chow Jesse,
Oda Yoshiya,
Kaplow June,
Albala Bruce
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1870
Subject(s) - dosing , pharmacology , pharmacodynamics , medicine , chemistry , cerebrospinal fluid , pharmacokinetics
Figure 2. Correlation Between CSF BACE1 Activity Levels and CSF Ab 1-x levels in All Monkey Samples Mark Matijevic, Hideki Watanabe, Yoshiaki Sato, Francois Bernier, Shannon McGrath, Lynne Burns, Noboru Yamamoto, Makoto Ogo, Zoltan Dezso, Jesse Chow, Yoshiya Oda, June Kaplow, Bruce Albala, Eisai, Andover, MA, USA; Eisai, Tsukuba, Japan; Formerly Eisai (when work was completed), Worcester, MA, USA; Eisai, Woodcliff Lake, NJ, USA; Eisai,Woodcliffe Lake, NJ, USA. Contact e-mail: mark_matijevic@eisai.com