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Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2
Author(s) -
Jack Clifford R.,
Barnes Josephine,
Bernstein Matt A.,
Borowski Bret J.,
Brewer James,
Clegg Shona,
Dale Anders M.,
Carmichael Owen,
Ching Christopher,
DeCarli Charles,
Desikan Rahul S.,
FennemaNotestine Christine,
Fjell Anders M.,
Fletcher Evan,
Fox Nick C.,
Gunter Jeff,
Gutman Boris A.,
Holland Dominic,
Hua Xue,
Insel Philip,
Kantarci Kejal,
Killiany Ron J.,
Krueger Gunnar,
Leung Kelvin K.,
Mackin Scott,
Maillard Pauline,
Malone Ian B.,
Mattsson Niklas,
McEvoy Linda,
Modat Marc,
Mueller Susanne,
Nosheny Rachel,
Ourselin Sebastien,
Schuff Norbert,
Senjem Matthew L.,
Simonson Alix,
Thompson Paul M.,
Rettmann Dan,
Vemuri Prashanthi,
Walhovd Kristine,
Zhao Yansong,
Zuk Samantha,
Weiner Michael
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.05.002
Subject(s) - neuroimaging , alzheimer's disease neuroimaging initiative , clinical trial , magnetic resonance imaging , medicine , diffusion mri , disease , psychology , alzheimer's disease , medical physics , radiology , psychiatry , pathology
Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods We review the contributions of the MRI core from present and past cycles of ADNI (ADNI‐1, ‐Grand Opportunity and ‐2). We also review plans for the future‐ADNI‐3. Results Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.