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P2‐171: CLINICAL CHARACTERISTICS OF DEMENTED PATIENTS WITH PROLONGED STAYS IN A PSYCHIATRIC HOSPITAL IN JAPAN
Author(s) -
Arai Tetsuaki,
Abe Shuzo,
Kurita Hirofumi,
Ikeda Manabu,
Eboshida Akira,
Kitamura Tatsuru,
Matsuoka Teruyuki,
Yasuno Fumihiko,
Yokota Osamu,
Asada Takashi
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.847
Subject(s) - dementia , medicine , psychiatry , severe dementia , anxiety , disease , dementia with lewy bodies , vascular dementia , depression (economics) , economics , macroeconomics
85% in CSF 14-3-3 protein. The most frequent vague symptom that patients experienced was dizziness and it prolonged for more than 3.5 months accompanied by incremental complex vague symptoms. DWI imaging is the most sensitive study in stage 2 and its high detection rate has tendency to maintain until the last stage. When we analysis the region of DWI high signal as subdividing neocortex, limbic cortex and subcortical nucleus, there was the highest signal rate in neocortex during the stage 2. But as the disease was progress, the signal rate of limbic cortex was increasing and finally became the highest rate in stage 5. The more disease progress, the more periodic sharp wave was detected in EEG and showed the highest detection rate in stage 5. On the other hand, the sensitivity of CSF 14-3-3 protein was rather decreased in terminal stage.Conclusions: Sporadic CJD patients usually have initial vague symptoms which persist for more than 3 months followed by other complex vague symptoms. At this period, it can help early suspicion about CJD to take DWI MRI than any other test.