Premium
IC‐P‐190: DETECTION OF LOCAL DYSFUNCTION IN ALZHEIMER'S DISEASE USING RESTING‐STATE FUNCTIONAL MRI
Author(s) -
Brier Matthew R.,
Mitra Anish,
Benzinger Tammie,
Morris John Carl,
Ances Beau
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.197
Subject(s) - resting state fmri , region of interest , functional connectivity , posterior cingulate , neuroscience , alzheimer's disease , functional magnetic resonance imaging , disease , medicine , psychology , radiology
volume measured ex-vivo and age-related neuropathologies, controlling for age at death, sex, education, height, postmortem interval to fixation and to imaging. Results: It was demonstrated that the total WMH volume was significantly associated with the summary measure of AD pathology (p1⁄40.003) and gross chronic infarcts (p1⁄40.0007).Conclusions:The results of this study offer support to the hypotheses that WMHs may result from Wallerian degeneration secondary to neurodegenerative changes, or from ischemia leading to both vascular injury and neurodegenerative changes of AD. To our knowledge, this study is the largest MRI-pathology investigation of WMHs in a community cohort to date. This is an ongoing study. Additional neuropathologies will be considered.