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IC‐P‐163: HIPPOCAMPAL GREY MATTER ATROPHY IS ASSOCIATED WITH THE FREE AND CUED SELECTIVE REMINDING TEST
Author(s) -
Meiberth Dix,
Burkei Eva,
Block Wolfgang,
Scheef Lukas,
Schild Hans H.,
Heneka Michael T.,
Wagner Michael,
Frommann Ingo,
Röske Sandra,
Hu Xiaochen,
Jessen Frank
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.170
Subject(s) - episodic memory , psychology , audiology , atrophy , recall , neuropsychology , free recall , medicine , cognition , neuroscience , cognitive psychology
SMC group, A+N showed cortical thinning in the left/right parietal inferior and superior regions (p<.028), temporal middle and superior temporo-lateral gyri (p1⁄4.05), left inferior frontal gyrus (p1⁄4.009), right lateral fusyform gyrus (p<.002), insula and precentral sulcus (p1⁄4.01). SNAP patients compared to SMC exibithed cortical thinning in the left central sulcus (p1⁄4.025), right superior and inferior tempro-lateral (p<.002) and parietal gyri (p1⁄4.04), and precentral sulcus (p1⁄4.011). The direct comparison between A+N and SNAP showed significant cortical thinning only in theA+Ngroup in the right and left lateral fusyform gyrus (p<.039), left occipital middle and lingual gyri (p1⁄4.020 and p1⁄4.007), parietal regions (p<.049) and orbito-lateral sulcus (p1⁄4.041). Both SNAP and A+N groups compared to SMC showed substantial subcortical volume reductions bilaterally in the hippocampus (p<.05), the nucleus accumbens (p<.046), the right pallidum (p<.0401), the left amygdala (p<.005). The direct comparisons between the two patient groups revealed a significant right amygdala atrophy in A+N patients. Conclusions: Our results support the hypothesis that SNAP patients are characterized by a different cortical and subcortical involvement relative to A+N due to different underlying pathologic changes.