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IC‐O1–05: APOE‐ε4 is associated with increased hippocampal atrophy rates in Alzheimer's disease
Author(s) -
Manning Emily,
Barnes Josephine,
Cash David,
Bartlett Jonathan,
Leung Kelvin,
Ourselin Sebastien,
Fox Nick
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.020
Subject(s) - atrophy , hippocampal formation , hippocampus , medicine , alzheimer's disease , cardiology , apolipoprotein e , psychology , neuroscience , disease
tion (PIB-PET) in ApoE4+ AD and ApoE4AD subjects. A) Differences in ApoE groups compared with controls. Maps show t-values corrected for multiple comparisons (FWE p<0.05). B) Direct comparison between ApoE AD groups. Shown are statistical t-maps at uncorrected threshold of p<0.01 for FDG, and FWE-corrected (p<0.05) for PIB ApoE4> ApoE4+, and uncorrected at p<0.05 for ApoE4+ > ApoE4-. Shown are also percent difference maps (-10% to 10%) to provide a fuller characterization of the FDG and PIB patterns, with red indicating higher FDG/PIB uptake in the ApoE4-patients compared with ApoE4+, and blue indicating the reverse contrast. Oral Sessions: IC-O1: Imaging Populations at Genetic Risk for Alzheimer’s Disease P5