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P3‐232: Mild cognitive impairment subjects with neuroimaging markers of Alzheimer's disease and cerebrovascular disease are more cognitively impaired than mild cognitive impairment subjects with Alzheimer's disease alone
Author(s) -
Chen Christopher,
YanHong Dong,
Tay Stephen Ziyang,
Wong Tien Yin,
Hilal Saima,
Catindig Joseree Ann,
Soon Hock Wei,
Wang Yanbo,
Ting Eric Y.S.,
Qiu Anqi,
Ikram Mohammad Kamran,
Venketasubramanian N.
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1454
Subject(s) - neuroimaging , neuropsychology , atrophy , psychology , cognition , disease , dementia , neuropsychological assessment , magnetic resonance imaging , medicine , alzheimer's disease neuroimaging initiative , stroke (engine) , pathological , audiology , pathology , neuroscience , radiology , mechanical engineering , engineering
demonstrably strong loadings on d. All observed variables were adjusted for age, gender and education. Conclusions: A latent variable approach to dementia case finding can result in highly accurate dementia endophenotypes. In this case, d has been constructed entirely from verbal measures which could be administered over the telephone in less than 30 minutes. Because a latent construct is “error-free,” we were able to accurately predict the diagnoses of blind clinicians using a verbal battery in a minority sample with demonstrably low educational attainment and variable acculturation. Moreover, the resulting latent construct can be output as a continuous variable, representing dementia’s endophenotype in Hispanics. This can be interrogated for its serum and genetic biomarkers.