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P3‐042: Effect of APOE genotype on hippocampal mitochondria in response to a mild ischemic challenge
Author(s) -
Searcy James,
James Rachel,
Le Bihan Thierry,
Martin Sarah,
Deighton Ruth,
Kerr Lorraine,
McCulloch James,
Horsburgh Karen
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1481
Subject(s) - apolipoprotein e , mitochondrion , biology , genotype , medicine , endocrinology , microbiology and biotechnology , biochemistry , disease , gene
ited to vascular boundaries, most commonly within phagocytes. By 36 weeks of treatment, the gaps found in both the smooth muscle and collagen layers in affected vessels returned to control levels. Conclusions: Our data indicate that during VAB clearance by immunotherapy, microhemorrhage increases over baseline levels but is transient and resolves on a time-course that is consistent with normalization of vessel integrity.