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P4‐144: Serum Pro and Total BDNF is the Candidate Biomarker for Elderly Depressed Patients and Treatment Response.
Author(s) -
Lim Shinn-Won,
Kim Doh Kwan,
Kim Suyeon,
Kim Jin-Woo,
Kim Soyeon
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.203
Subject(s) - antidepressant , depression (economics) , behavioural despair test , medicine , brain derived neurotrophic factor , volunteer , biomarker , psychology , neurotrophic factors , hippocampus , oncology , endocrinology , receptor , biology , biochemistry , chemistry , agronomy , economics , macroeconomics
83.36 10 and 60.66 9.4 (p< 0.0001); Linguistic Comprehension: 98.76 5.3 and 91.16 6.6 (p1⁄4 0.0001), and Visuospatial Construction: 24.66 1.7 and 19.26 4.2 (p < 0.0001). Total score of ABCD was 83.26 4.8 for controls and 67.2 6 6.7 in the VaD group (p < 0.0001). Linguistic Expression tasks were more effective in discriminating VaD patients from controls than Linguistic Comprehension tasks. Conclusions: The ABCD is a useful tool to identify and discriminate linguistic performance of VaD patients from normal elderly. Executive dysfunction (including working memory), and attentional impairment, may have influenced the patients’ linguistic performance.