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P1‐036: Seeding of cross linked alpha‐synuclein oligomers in vitro and in vivo
Author(s) -
Wahlberg Therese,
Nasstrom Thomas,
Sahlin Charlotte,
Ingvast Sofie,
Karlsson Mikael,
Nikolajeff Fredrik,
Ekberg Monica,
Kasaryan Alex,
Schell Heinrich,
Kahle Philipp J.,
Lannfelt Lars,
Bergstrom Joakim,
Ingelsson Martin
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.583
Subject(s) - in vivo , dementia with lewy bodies , fibril , chemistry , thioflavin , in vitro , monomer , biophysics , alpha synuclein , protein aggregation , amyloid (mycology) , ex vivo , biochemistry , parkinson's disease , alzheimer's disease , pathology , biology , dementia , polymer , disease , medicine , inorganic chemistry , microbiology and biotechnology , organic chemistry
We evaluated the correlation between each fractional anisotrophy (FA) and depression scores. Methods: Nineteen SIVD patients underwent DTI. Total 30 ROIs were measured. We conducted the correlation analysis between the depression scores FA in each 30 ROI. Results: In SIVD patients, there is a tendency of lower values of FA in the posterior body of the corpus callosum as the depression scores are getting higher.(r 1⁄4 -0.462, p < 0.05) On the other hand, there is a tendency of higher values of FA in the left temporal white matter region as the depression scores are getting higher.(r 1⁄4 0.456, p < 0.05) Conclusions: Lower FA of posterior body of the corpus callosum might imply underlying structural abnormalities that contribute to the depressive mood in SIVD patients. Higher FA of left temporal region might cause depressive mood. However, the exact mechanism how the higher left temporal FA correlates with depressive mood is not elucidated. Further large scale study should be followed to determine the roles of altered FA values in the corpus callosum and left temporal area in the pathogenesis of depression mood.