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O4‐07‐05: Improving cardiovascular risk management in elderly to prevent dementia: The preDIVA trial in progress
Author(s) -
Ligthart Suzanne A.,
Richard Edo,
Moll van Charante Eric P.,
Gool Willem A.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.508
Subject(s) - medicine , dementia , blood pressure , physical therapy , vascular dementia , overweight , stroke (engine) , incidence (geometry) , randomized controlled trial , myocardial infarction , diabetes mellitus , disease , body mass index , mechanical engineering , physics , optics , engineering , endocrinology
working memory, speed of processing, and spatial problem solving. To assess the neurobiological effects of cognitive training, event-related potentials (ERPs) were measured in a subset of participants during performance of a source memory task. Follow-up testing will be conducted immediately post cognitive training and at six monthly intervals for a 2 year follow-up period. A control group (N1⁄4 300, Age1⁄4 61.90, SD1⁄4 7.16 yrs) completed the computerized test battery at 3-monthly intervals for 1 year. Results: Results from the follow-up testing conducted immediately post cognitive training indicate that, compared to controls, ACE participants showed significantly improved performance on cognitive function tests measuring visual learning and memory, attention/working memory, and executive function. Small, but non-significant, improvements in measures of processing speed were also observed. ACE participants also reported significant improvement in everyday memory functioning and increased physical exercise. Results from the 6 and 12-month follow-up testing will be available at the time of the conference. Conclusions: Preliminary results indicate that providing older adults with cognitive training produced immediate post-training improvements on tests of cognitive function and subjective measures of everyday memory. Of particular importance will be to determine whether these immediate improvements in cognitive function are maintained in the longer-term follow-up testing.