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P4–378: Effects of donepezil against degeneration of the basalocortical cholinergic system induced by cortical devascularisation in the adult rat
Author(s) -
Hirsch Etienne,
Ginestet Laure,
Raisman-Vozari Rita,
Debeir Thomas
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2119
Subject(s) - donepezil , vesicular acetylcholine transporter , nucleus basalis , cholinergic , acetylcholine , acetylcholinesterase , choline acetyltransferase , acetylcholinesterase inhibitor , cholinergic neuron , neurotransmitter , neuroscience , medicine , pharmacology , chemistry , biology , receptor , dementia , disease , biochemistry , enzyme
sessment tests. The patients received cholinesterase inhibitors. The intervention program was individualized and lasted about four months with three hours a week of sessions and home exercises for the rest of the weekdays. The basic techniques of the cognitive program were memory strategies, errorless learning and extended repetition. Results: Comparing the preand post-test results after six months of the end of the intervention we found statistically significant differences between the 2 groups of AD to a battery of neuropsychological tests (e.g., MMSE, CAMCOG, Pyramids and Palm Trees, Boston Naming Test, Wisconsin, Rivermead Behavioural Memory Test, and Alzheimers Quick Screen p.05). Conclusions: The mild AD patients can improve their impaired cognitive abilities after a cognitive intervention program of 4 months duration and maintain this improvement at least ten months after the beginning of the program. The normal aging people perhaps need more difficult programs adjusted to their cognitive state in order to improve their mental state.