Open AccessSelection of phage-displayed human antibody fragments specific for CD1b presenting the Mycobacterium tuberculosis glycolipid Ac2SGL
Author(s) -
Frank Camacho,
María E. Sarmiento,
Fátima Reyes,
Louise U. Kim,
Jim F. Huggett,
Marco Lepore,
Oscar Otero,
Martine Gilleron,
Germain Puzo,
Mohd Nor Norazmi,
G.A.W. Rook,
Lucia Mori,
Gennaro De Libero,
Armando Acosta
Publication year - 2016
Publication title -
international journal of mycobacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 20
eISSN - 2212-554X
pISSN - 2212-5531
DOI - 10.1016/j.ijmyco.2015.12.002
Subject(s) - mycobacterium tuberculosis , glycolipid , antibody , microbiology and biotechnology , selection (genetic algorithm) , biology , tuberculosis , mycobacterium , negative selection , virology , bacteria , immunology , genetics , gene , medicine , computer science , genome , pathology , artificial intelligence
The development of new tools capable of targeting Mycobacterium tuberculosis (Mtb)-infected cells have potential applications in diagnosis, treatment, and prevention of tuberculosis. In Mtb-infected cells, CD1b molecules present Mtb lipids to the immune system (Mtb lipid-CD1b complexes). Because of the lack of CD1b polymorphism, specific Mtb lipid-CD1b complexes could be considered as universal Mtb infection markers. 2-Stearoyl-3-hydroxyphthioceranoyl-2'-sulfate-α-α'-d-trehalose (Ac2SGL) is specific for Mtb, and is not present in other mycobacterial species. The CD1b-Ac2SGL complexes are expressed on the surface of human cells infected with Mtb. The aim of this study was to generate ligands capable of binding these CD1b-Ac2SGL complexes.
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