Open AccessKrüppel‐like factor 4 induces apoptosis and inhibits tumorigenic progression in SK‐BR‐3 breast cancer cells
Author(s) -
Wang Bing,
Zhao Ming-zhi,
Cui Nai-peng,
Lin Dan-dan,
Zhang An-yi,
Qin Yan,
Liu Cai-yun,
Yan Wei-tao,
Shi Jian-hong,
Chen Bao-ping
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2015.02.003
Subject(s) - klf4 , apoptosis , cancer research , oncogene , cancer , breast cancer , biology , medicine , transcription factor , cell cycle , sox2 , gene , biochemistry
Krüppel‐like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor‐α–induced SK‐BR‐3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK‐BR‐3 breast cancer cell apoptosis and suppressed SK‐BR‐3 cell tumorigenicity in vivo .