Open AccessRegulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster
Author(s) -
Srivastava Ajay,
Dong Qian
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2015.01.008
Subject(s) - phenocopy , drosophila melanogaster , microbiology and biotechnology , context (archaeology) , biology , kinase , serine protease , signal transduction , phenotype , morphogenesis , serine , protease , phosphorylation , genetics , gene , enzyme , biochemistry , paleontology
The importance of the Jun N‐terminal Kinase (JNK) pathway during normal development and tumor invasion has been well documented in Drosophila . Here, this pathway plays important roles in epithelial morphogenesis, wound healing, apoptosis, immunity and regulation of lifespan. However, which downstream molecules facilitate these effects is not very well elucidated. In this study, data are presented on a serine protease homolog (SPH), scarface . These data show that scarface is under regulatory control of the JNK pathway and that this pathway is both necessary and sufficient for its expression within the context of thoracic development. Consequently, down‐regulation of scarface results in a thoracic‐cleft phenotype that phenocopies the JNK pathway defect. A possible role of scarface during thoracic development in Drosophila is discussed.